ANAT 565. Diseases-Membrane Trafficking.

This course will examine how research into diseases has played a key role in unraveling the intricate molecular mechanisms controlling membrane trafficking in mammalian cells. Membrane trafficking disorders fall into two groups those arising from a) membrane-associated or b) cytoskeletal defect. Topics include a) mechanisms of endosomal maturation, lysosomal storage disorders and rab protein-mediated vesicular trafficking and b) rho GTPase and cytoskeletal binding protein mediated trafficking associated with neurological diseases and cancer.