BTEC 650. Therapeutic Antibody Design.
Credits: 3
Offered by: Parasitology (Graduate Studies)
Terms offered: Fall 2025
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Description
Principles and methodologies of structure-based molecular design, optimization, and development of therapeutic monoclonal antibodies. Role in therapy and diagnosis;
structural features of various types of antibodies; dissection of antibody-antigen interactions; in silico affinity maturation; manipulation of antigen specificity by point mutagenesis; using antibody Fc domain to modulate pharmacokinetics and
effector functions; design of antibody conjugates carrying toxic payloads; engineering T-cells with chimeric antigen receptors; evaluation and improving antibody immunogenicity and aggregation; antibody humanization.
- Prerequisite: 400-level or higher level course in biochemistry and bioinformatics, or permission of instructor